COLUMBIA, S.C. (WCBD) –- South Carolina’s lead health agency said Wednesday that there are no known cases of monkeypox in the state.

It comes a day after the South Carolina Department of Health and Environmental Control announced it was monitoring two close contacts who were on a flight with someone from the United Kingdom who had tested positive for monkeypox.

DHEC will end its monitoring of those two contacts.

“The close contacts were being observed in the Midlands region of the state and remained asymptomatic through the 21-day monitoring period, which began May 5 and ended Wednesday at noon,” DHEC said. “There have been no confirmed cases of monkeypox in South Carolina.”

The health agency said monkeypox is a rare but potentially serious viral illness that usually begins with flu-like symptoms and swelling of the lymph nodes and progresses to a rash on the face and body.

“Monkeypox does not spread easily between people. It can be spread through close contact with an infected person and their skin sores, items that have been contaminated with fluids or sores (clothing, bedding, etc.), or through respiratory droplets. following prolonged face-to-face contact,” explained DHEC.

Doctors are asked to report a suspected case to DHEC, who will then investigate and conduct testing to confirm or rule out a case.

Those who think they are experiencing symptoms should see their primary doctor.